Journal of Dental Research, Vol 63, 32-36, Copyright © 1984 by International & American Associations for Dental Research Online Journals
An incisor plaque model in rats
B. R. Schemehorn, J. L. McDonald, G. K. Stookey and K. K. Park
An in vivo model for studying plaque accumulation in rats has been
described. This model investigates plaque formation on the mandibular
incisors in animals which have been found to be rapid plaque-formers during
a pre-test period. The accessibility of these tooth surfaces permits the
removal of plaque prior to initiation of tests, the use of test groups
balanced on the basis of plaque-forming potential, and interim assessments
of plaque formation throughout the test period. In addition, baseline
plaque scores of near zero can be attained, thereby permitting
investigations of the impact of experimental measures on plaque formation.
Moreover, the model permits intermittent plaque assessments throughout the
test period. This model was found to have adequate sensitivity to
distinguish effects between antimicrobial agents known to differ in their
clinical activity and to detect differences between varying concentrations
of the same agent.
