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Journal of Dental Research, Vol 62, 870-872, Copyright © 1983 by International & American Associations for Dental Research Online Journals

ARTICLES

Juvenile periodontitis as a model for neutrophil function: reduced binding of the complement chemotactic fragment, C5a

T. E. Van Dyke, M. J. Levine, L. A. Tabak and R. J. Genco

The binding of the chemotactic complement fragment, C5a, to peripheral blood neutrophils of Localized Juvenile Periodontitis (LJP) patients and normal controls was quantitated using iodinated human C5a and a rapid centrifugation assay. There was a significant reduction in the number of binding sites per cell on neutrophils from the patient group, whereas the binding affinity remained the same as control values.




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