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Journal of Dental Research, Vol 62, 725-727, Copyright © 1983 by International & American Associations for Dental Research Online Journals


ARTICLES

Effects of androgens on the activity of steroid-metabolizing enzymes in the murine submaxillary gland

H. Katsukawa, Y. Tanabe and M. Funakoshi

Effects of androgens on the activity of androgen-metabolizing enzymes have been investigated in the murine submaxillary gland. 5 alpha-reductase activity is androgen-dependent, and 17 beta-hydroxysteroid dehydrogenase activity is androgen-resistant. The level and androgen-responsiveness of 5 alpha-reductase in the murine submaxillary gland are not imprinted during the neonatal period by testicular androgens. Circulating androgen may have a cumulative effect on androgen response of 5 alpha-reductase.





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