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Journal of Dental Research, Vol 62, 559-561, Copyright © 1983 by International & American Associations for Dental Research Online Journals


ARTICLES

Effect of dichloromethylene diphosphonate on fluoride balance in healthy men

U. R. Maheshwari, L. Leybin, J. T. McDonald, V. S. Schneider, E. Newbrun and H. C. Hodge

Healthy men with a daily intake of 0.37 mg fluoride were given dichloromethylene diphosphonate (Cl2MDP) or a placebo during a period of ambulation followed by bed rest. In both groups, serum ionic fluoride was unchanged, and fluoride balances were negative, but Cl2MDP significantly reduced loss of fluoride in the treated groups.





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