Journal of Dental Research, Vol 60, 1432-1439, Copyright © 1981 by International & American Associations for Dental Research Online Journals
Evaluation of an oligomer or an oligomer plus cetyl pyridinium chloride against plaque, stain, calculus, and gingivitis
A. Gaffar, H. P. Niles and C. B. Davis
A low molecular weight oligomer of sulfoacrylic acid (ND-2) was effective
in inhibiting hydroxyapatite formation in vitro at 33 ppm from a saturated
solution of calcium and phosphate. The oligomer did not damage or etch
human dental enamel in vitro at pH 5.0 and 7.5. It significantly reduced
calculus formation when applied topically in beagles at a concentration of
1% in a rinse. In a second study using 30 beagle dogs, the rinses
containing 0.1% CPC and 0.1% CPC + 2% ND-2 significantly reduced (alpha
less than 0.05) plaque and gingivitis for 12 wk when compared to a placebo
rinse. One-tenth percent CPC rinse induced more discoloration of teeth than
the placebo, while the rinse containing 0.1% CPC + 2% ND-2 had
significantly less discoloration than CPC rinse or the placebo rinse in
beagles. Thus the oligomer was effective in reducing CPC-induced
discoloration in beagles.
