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Journal of Dental Research, Vol 60, 1427-1431, Copyright © 1981 by International & American Associations for Dental Research Online Journals

ARTICLES

Blood and urine fluoride concentrations associated with topical fluoride applications on dog gingiva

J. Hock, C. Gerber, M. Rheaume and L. Hellden

The circulatory uptake and urinary excretion of topical fluoride were investigated by applying a sodium fluoride solution containing 18F for six min to healthy gingiva of four adult dogs. Blood and urine samples were taken a regular intervals. Maximal fluoride in blood represented 0.02-0.05% of the applied dose and occurred four min after completion of the application. By 6.0 h, 0.02-0.06% of the applied dose had been excreted in urine. Preliminary data showed that this represented about 8.8% of the fluoride absorbed through the gingiva.




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