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Journal of Dental Research, Vol 59, 1466-1472, Copyright © 1980 by International & American Associations for Dental Research Online Journals

ARTICLES

Hypothiocyanite ion: detection of the antimicrobial agent in human saliva

E. L. Thomas, K. P. Bates and M. M. Jefferson

The median concentration of hypothiocyanite (OSCN-) in freshly collected whole saliva was 10 microM. The OSCN- concentration increased to a median value of 36 microM during incubation for one h at 37 degrees in vitro. This increase was partially inhibited by adding certain sugars (especially sucrose). The results suggest that OSCN- is a naturally occurring component of human saliva. Also, dietary carbohydrate may inhibit OSCN- accumulation and antimicrobial action in saliva.


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M. T. Ashby
Inorganic Chemistry of Defensive Peroxidases in the Human Oral Cavity
J. Dent. Res., October 1, 2008; 87(10): 900 - 914.
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