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Journal of Dental Research, Vol 59, 1075-1080, Copyright © 1980 by International & American Associations for Dental Research Online Journals

ARTICLES

DNA synthesis of enamel organ epithelium in vitro is enhanced by co-cultivation with non-viable mesenchyme cells

A. G. Brownell and L. J. Rovero

Developing enamel organ epithelium was cultured in the presence and absence of non-viable dental papilla mesenchyme cells. Epithelial cell proliferation was enhanced by 75% when cultivated on the mesenchyme cell substratum. The addition of epidermal growth factor (EGF) to enamel organ epithelium cultured on this substratum resulted in a synergistic enhancement of DNA synthesis.




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Journal of Dental Research ® Critical Reviews (1990-2004)
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