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Journal of Dental Research, Vol 59, 670-674, Copyright © 1980 by International & American Associations for Dental Research Online Journals

ARTICLES

Metabolism of arachidonic acid in inflamed human gingivae. I.: Formation of 6-keto-prostaglandin F1 alpha

P. Y. Wong, J. R. Ross and F. D. Sticht

Incubation of [14C]-arachidonic acid with slices of inflamed human gingivae in the absence of glutathione resulted in formation of 6-keto-PGF1 alpha, the stable hydrolytic product of prostacyclin. Significantly smaller amounts of this product were obtained when normal gingivae were treated in a similar manner. The formation of prostacyclin in inflamed gingivae may play an important role in alveolar bone resorption and as a mediator of inflammation in periodontal disease.




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