Journal of Dental Research, Vol 58, 1933-1939, Copyright © 1979 by International & American Associations for Dental Research Online Journals
Fluoride inhibition of polymorphonuclear leukocytes
W. L. Gabler and P. A. Leong
Significant inhibition of PMN metabolic activity by F- occurred at 0.1, 0.5
and 0.0 mM F- for O2- generation, 1-C14 CO2 release labeled glucose and
NBT-reduction respectively. This inhibition resulted primarily from F-
suppression of nonoxidative glucose metabolism. As the concentration of F-
in the O2- generating system increased beyond 10 mM, a rise in production
of O2- anion occurred, peaking at 20 mM F-, followed by a rapid decline.
