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Journal of Dental Research, Vol 58, 1812-1814, Copyright © 1979 by International & American Associations for Dental Research Online Journals

ARTICLES

Diphenylhydantoin induced gingival hyperplasia in ferrets: a precautionary note

P. A. Moore, J. W. Smudski and S. Hopper

Diphenylhydantoin appears to modify the tissue response in ferrets to a gingival irritant. In the present study, ferrets were tested for the tissue response to a local irritant in their maxillary right quadrant, while their maxillary left quadrant was the control. A low incidence of hyperplasia was induced only in irritated gingival tissue of animals receiving DPH. The problems encountered in comparing the hyperplasia produced in ferrets and humans were also discussed.




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