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Journal of Dental Research, Vol 58, 642-645, Copyright © 1979 by International & American Associations for Dental Research Online Journals

ARTICLES

Cellular regulation of the metabolism of androgens in rat oral mucosa. III. Activation of delta 4-3-ketosteroid-5alpha-A ring reductase enzyme system by 5,5-diphenylhydantoin

J. Vittek, G. G. Gordon, S. C. Rappaport and A. L. Southren

Systemic pretreatment of rats with diphenylhydantoin (DPH) or its addition into an in vitro assay increases 5alpha-reduction of testosterone by the oral mucosa. Enzyme kinetic studies showed that DPH binds to the enzyme and probably activates it by an allosteric mechanism.




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