Journal of Dental Research, Vol 58, 2396-2403, Copyright © 1979 by International & American Associations for Dental Research Online Journals
In vitro testing of plaque control agents
R. A. Coburn
The development of a number of in vitro techniques for the evaluation of
antiplaque effects of test agents has followed the characterization and
culturing of plaque-forming microorganisms. Studies of the mechanism of
action of chlorhexidine and clinical observations have assisted in defining
critical aspects of these in vitro techniques. Such assays may play an
increasingly important role in screening potential new agents as well as in
the optimization of properties by chemical modification of new lead agents.
In addition, data generated in the in vitro assay may assist the design of
in vivo evaluations of new agents. Proper selection of in vitro techniques
for these various functions in the pre-clinical development process may
reduce the time and cost involved in the development of new antiplaque
agents.
