Journal of Dental Research, Vol 57, 625-630, Copyright © 1978 by International & American Associations for Dental Research Online Journals
Immunotherapy of chemically-induced tumors in the hamster cheek pouch with dinitrochlorobenzene
M. Marshack, P. Toto and R. Kerman
Immune stimulation with an agent such as dinitrochlorobenzene (DNCB) may
delay chemical carcinogenesis. Dimethylbenzanthracene (DMBA) was used to
chemically induce tumors in the hamster buccal pouch. Hamsters were studied
for the effect of DNCB sensitization in the buccal pouch prior to or after
DMBA tumor induction. At appropriate time intervals the hamsters were
sacrificed and each cheek pouch was examined histologically for the
development of DMBA-induced tumors and for the presence of lymphoid cells
infiltrating the tumor site. The results show that DNCB immunotherapy or
immunoprophylaxis prior to or following DMBA tumor induction can alter the
type of tumor produced and stimulate an infiltration of lymphoid cells into
the tumor area probably invoking immune defense mechanisms.
