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Journal of Dental Research, Vol 57, 511-519, Copyright © 1978 by International & American Associations for Dental Research Online Journals

ARTICLES

Effect of progestins on androgen delta4-3-ketosteroid-5alpha-A-ring reductase system in rat oral mucosa

J. Vittek, K. Altman, S. C. Rappaport, G. G. Gordon, J. Hagedorn and A. L. Southren

Rat oral mucosa microsomal delta4-3-ketosteroid-5alpha-A-ring reductase enzyme system, reducing testosterone and 4-androstenedione, was found to be inducible by systemic administration of medroxyprogesterone acetate (MPA). MPA, when used in a mixture with testosterone and/or 4-androstenedione in vitro, acted as a competitive inhibitor of the reduction of these substrates.




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Journal of Dental Research ® Critical Reviews (1990-2004)
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