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Journal of Dental Research, Vol 56, 559-567, Copyright © 1977 by International & American Associations for Dental Research Online Journals

ARTICLES

Comparison of antiplaque agents using an in vitro assay reflecting oral conditions

R. T. Evans, P. J. Baker, R. A. Coburn and R. J. Genco

An in vitro assay is described using saliva-treated bovine enamel slabs for determining the potential of chemotherapeutic agents to adsorb to tooth surfaces and act against plaque-forming bacteria. Chlorhexidine was found to inhibit the formation of in vitro plaque by Actinomyces viscosus, A naeslundii, Streptococcus mutans and S sanguis. Actinobolin was found to have marked antibacterial properties but limited adsorptive qualities.




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