Journal of Dental Research, Vol 56, 105-107, Copyright © 1977 by International & American Associations for Dental Research Online Journals
HL-A histocompatibility antigens in recurrent aphthous ulceration
A. E. Dolby, D. M. Walker, M. Slade and C. Allan
The frequency of HL-A phenotypes has been investigated in 64 patients who
had recurrent aphthous ulcers and 100 subjects who did not. The HL-A
phenotypes were determined by a two-step microcytotoxicity test on
peripheral blood lymphocytes, incubating these cells with a range of
defined antiserums and complement and subsequently assessing lymphocyte
viability by dye exclusion. There were no significant differences between
the frequency of individual HL-A antigens in the patients with aphthous
ulceration and those of subjects without aphthous ulceration. Similarly, no
differences in numbers of shared antigens could be demonstrated. The
distribution of HL-A antigens was essentially similar in subdivisions of
patients with aphthous ulceration, grouped on the basis of sex, family
history, age at onset, and maximum number of concurrent ulcers and their
duration before healing.
