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Journal of Dental Research, Vol 56, 1391-1394, Copyright © 1977 by International & American Associations for Dental Research Online Journals

ARTICLES

Lidocaine's influence on the accumulation and depletion rates of mouse brain amines

A. E. Ciarlone and J. W. Smudski

Mouse brain was analyzed for serotonin, norepinephrine, and dopamine. Pargyline plus lidocaine treatment caused an increased accumulation rate of serotonin over one hour compared to pargyline controls. alpha Methyl-p-tyrosine plus lidocaine treatment caused a decreased depletion rate of dopamine over four hours compared to rates of alpha methyl-p-tyrosine controls, and no difference for norepinephrine.




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