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Journal of Dental Research, Vol 56, 83-88, Copyright © 1977 by International & American Associations for Dental Research Online Journals

ARTICLES

Rate of permeation of isotopes through human dentin, in vitro

D. H. Pashley, M. J. Livingston and W. C. Outhwaite

A simple in vitro method has been described for quantitatively measuring the rate at which isotopically labeled substances permeate through dentin in occlusal cavity preparations. The presence or absence of pulp tissue had only a minor effect on the kinetics of permeation. As the dentin was made thinner there was a resulting increase in the rate of iodide permeation. The relative rates of permeation were 3H2O greater than 131I greater than 99mTc greater than 14C-urea, a sequence that follows the molecular dimensions of these substances.




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