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Journal of Dental Research, Vol 55, 841-847, Copyright © 1976 by International & American Associations for Dental Research Online Journals

ARTICLES

Chromatographic properties of denatured skin and bone collagens on hydroxyapatite

C. F. Nawrot, J. K. Mittelstadt and M. Kuo

Denatured collagen samples extracted from the skin and bone of lathyritic rats with guanidine hydrochloride were chromatographed on hydroxyapatite columns. A major fraction of the bone extract that was rich in alpha chain showed a stronger binding to hydroxyapatite when compared to the corresponding fraction from skin. Thus, bone collagen shows a special affinity for hydroxyapatite after isolation and denaturation.




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Journal of Dental Research ® Critical Reviews (1990-2004)
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