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Journal of Dental Research, Vol 55, 465-469, Copyright © 1976 by International & American Associations for Dental Research Online Journals
ARTICLES |
A. E. Ciarlone and J. W. Smudski
This series of experiments suggests that a relationship exists between convulsive doses of lidocaine and central depletion of 5-HT and DA. Since DA and usually 5-HT are regarded as central inhibitory transmitters, this study further supports the postulate that lidocaine's convulsive activity is by inhibition of central inhibitory pathways-possibly a dopaminergic or tryptaminergic pathway or both.
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