Journal of Dental Research, Vol 55, 229-234, Copyright © 1976 by International & American Associations for Dental Research Online Journals
Experimental carcinogenesis in duct-artery ligated rat submandibular gland
A. Englander and E. Cataldo
In an attempt to shorten tumor induction time and alter tumor
anaplasticity, ductal metaplasia was induced in the submandibular gland of
30 rats by ligation of the duct and artery followed by the implanation of
4-mg pellets of pure DMBA. Control groups consisted of 19-ligated and
15-DMBA implanted rats. The ligate controls showed degeneration and atrophy
of the affected gland and replacement of glandular tissue by scar tissue.
The DMBA controls followed the expected pattern, with all rats eventually
developing well-differentiated squamous cell carcinoma. The CMBA-ligated
rats showed a combination of the two processes, each acting separately from
the other. There was no difference either in induction time or tumor
anaplasticity between the DMBA control rats and the DMBA-ligated rats. It
seems that only factors relating to a change in the immunologic response of
the host affect the latent period of tumor induction time in submandibular
gland carcinogenesis.
