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Journal of Dental Research, Vol 55, 130-134, Copyright © 1976 by International & American Associations for Dental Research Online Journals

ARTICLES

A physiochemical approach to the study of amines as antiplaque agents

V. D. Warner, A. M. Warner, D. B. Mirth, J. N. Sane, S. S. Turesky and B. Soloway

Alkyl and aromatic amines were evaluated for inhibitory activity against S mutans 6715. Only the alkylamines were active and this may be due to their greater basicity. The agents that showed good activity were decylamine, dodecylamine, tetradecylamine, and hexadecylamine. In addition to the free bases, the hydrochloride and hydrofluoride salts were also tested for inhibitory activity and the same four agents were shown to be most active. These agents appear to hold good promise as antiplaque agents against S mutans 6715, therefore, further in vitro studies against other plaque-forming bacteria and toxicological and clinical evaluation seems to be warranted to determine the best clinical agent.




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