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J Dent Res 54(6): 1196-1199, 1975
© 1975 International and American Associations for Dental Research
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Feulgen Microspectrophotometry of Oral Cancer and Leukoplakia

JOHN L. DOYLE 1 and JOHN H. MANHOLD JR. 1

1 Department of General and Oral Pathology, New Jersey Dental School, College of Medicine and Dentistry, Jersey City, New Jersey 07304, USA

Feulgen microspectrophotometry was performed using the two wavelength method on 33 lesions and showed that five of ten carcinomas and 12 of 16 leukoplakias had diploid cell lines. This correlates well with similar findings in cervical cancer and dysplasia suggesting that changes in nuclear deoxyribonucleic acid content occur quite early in the evolution of cancer.

Submitted on September 6, 1974
Accepted on June 27, 1975






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