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J Dent Res 54(6): 1143-1148, 1975
© 1975 International and American Associations for Dental Research
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Localization of Rate-Limiting Barrier to Penetration of Endotoxin Through Nonkeratinized Oral Mucosa In Vitro

MICHAEL C. ALFANO 1, JAMES F. DRUMMOND 1, and SANFORD A. MILLER 1

1 Oral Science Laboratories, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

The penetration of tritiated bacterial endotoxin through nonkeratinized oral mucosal epithelium was studied using an in vitro model system and radioautographic tracer techniques. The basement membrane region of the epithelium was the rate-limiting barrier to penetration, and this barrier effect was independent of the direction and duration of penetration as well as any clearance effects of the vasculature.

Submitted on March 7, 1975
Accepted on June 30, 1975




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P.P. HUJOEL, M. DRANGSHOLT, C. SPIEKERMAN, and T.A. DEROUEN
Examining the link between coronary heart disease and the elimination of chronic dental infections
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