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J Dent Res 54(5): 926-930, 1975
© 1975 International and American Associations for Dental Research
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Effects of Short-Term and Long-Term Administration of Procaine Hydrochloride and Mepivacaine Hydrochloride on Hexobarbital-Induced Sleeping Times in Mice

DANIEL J. RINCHUSE 1 and JAMES W. SMUDSKI 1

1 Departments of Pharmacology and Physiology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA

Investigations were performed to determine the effects of short-and long-term pretreatment with procaine and mepivacaine on hexobarbital-induced sleeping times in mice. It was found that short-term preadministration with procaine (40 mg/kg) and mepivacine (40 and 60 mg/kg) significantly increased hexobarbital-induced sleeping time, but long-term pretreatment had no effect.

Submitted on October 21, 1974
Accepted on February 15, 1975






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