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J Dent Res 54(5): 1082-1086, 1975
© 1975 International and American Associations for Dental Research
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Inhibitory Effect of Apernyl on Production of Bradykininlike Substance in Pulp

TERUO KUDO 1, MASATAKA KAWAGOE 1, TAKESHI HAYASHI 1, JUN TAKEZAWA 1, and REIZO INOKI 1

1 Department of Pharmacology, Osaka University Dental School, Kitaku, Osaka, Japan

In the Formalin-induced pulpitis of rats and the electrically stimulated pulps of dogs, a bradykininlike substance developed by the pulps and released into a saline pool on the exposed pulps disappeared after a local application of Apernyl solution. This suggests that the possible pain-reducing or anti-inflammatory effect of Apernyl is a result of its inhibiting bradykinin production.

Submitted on February 26, 1973
Accepted on February 27, 1975






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