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J Dent Res 54(5): 1009-1014, 1975
© 1975 International and American Associations for Dental Research
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Effect of Metabolic Inhibitors on Bone Lipid Synthesis from Radioactive Bases

THOMAS R. DIRKSEN 1, GEORGE S. SCHUSTER 1, RALPH McKINNEY 1, and SERGIO E. BUSTOS 1

1 Departments of Oral Biology, Oral Pathology, Cell and Molecular Biology and Pathology, Schools of Dentistry and Medicine, Medical College of Georgia, Augusta, Georgia 30902, USA

lodoacetate at 10-3 M and 10-4 M concentrations was found to strongly inhibit incorporation of both 14C-choline and 3H-inositol into phospholipids of calvaria from newborn rats; it had somewhat less effect on ethanolamine incorporation and almost no effect on serine incorporation. Similar though less dramatic results were observed with cyanide or dinitrophenol at similar concentrations.

Submitted on August 8, 1974
Accepted on November 6, 1974






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