Effect of Infusing Selected Chemical Compounds on Dentinal Fluid Movement in the Rat

¹ Department of Oral Medicine, School of Dentistry, and Department of Physiology, School of Medicine, Loma Linda University, Loma Linda, California 92354, USA

Intra-arterial infusion of carbamyl phosphate or of carbamyl-DL-aspartic acid into rats on a cariogenic diet greatly stimulated the movement of fluid through the odontoblastic processes. The infusion of sodium cyanate also stimulated fluid movement. Guanidine HCl and L-asparagine were active at higher concentrations. Purifying the urea on a mixed-bed ion exchange resin virtually removed its stimulatory effect on dentinal fluid movement. The action of urea is apparently attributable to contamination with sodium cyanate.