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J Dent Res 54(3): 441-443, 1975
© 1975 International and American Associations for Dental Research
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Herpes Simplex Virus Type 1 Replication in a Gingival Cell Line

R. D. FLETCHER 1, J. GUGGENHEIMER 1, D. SUMNEY 1, and D. PLATT 1

1 School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA

Propagation of herpes simplex virus type 1 (HSV-1) in gingival cells is advantageous since these cells are more definitive than HeLa cells in demonstrating viral-induced cytopathic effects and are easily and economically maintained in the laboratory. They also provide a potential medium for studying oral tissue reactions to HSV-1 infection. HSV-1-induced cytopathic effects are cle(arly characterized following inoculation with viruts from standard laboratory cultures and human infections.

Submitted on July 15, 1974
Accepted on October 29, 1974






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