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J Dent Res 54(2): 358-364, 1975
© 1975 International and American Associations for Dental Research
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Effects of Repeated Oral Doses of Demethylchlortetracycline on Bones and Dentin of Young Rhesus Monkeys

PETER K-J. YEN 1 and JAMES H. SHAW 1

1 Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA

Seven oral doses of demethylchlortetracycline were administered to monkeys that received serial injections of lead acetate to intravitally stain calcification sites. Bone growth was greatly inhibited, whereas dentin apposition was spared from the cumulative toxicity of demethylchlortetracycline. Cessation of bone growth and its duration could be correlated with serum levels.

Submitted on May 20, 1974
Accepted on September 24, 1974






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