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J Dent Res 54(1): 62-64, 1975
© 1975 International and American Associations for Dental Research
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Parotid Saliva Enzymes in Down's Syndrome

RICHARD A. WINER 1 and HOWARD H. CHAUNCEY 1

1 Departments of Oral Health Service and Oral Pathology, School of Dental Medicine, Tufts University, Boston, Massachusetts 02111, USA, and the Veterans Administration Outpatient Clinic, St. Petersburg, Florida 33701

The parotid saliva in persons with Down's syndrome was analyzed for three enzymes: acid phosphatase, nonspecific esterase, and amylase. The results have shown a statistically significant elevation of esterase activity in persons with Down's syndrome whereas no statistical differences were observed with the other enzymes. The current investigation has provided further insight into salivary gland metabolism and may have yielded some information pertaining to the genetic control of the processes regulating the electrolyte concentration of human saliva.

Submitted on January 14, 1974
Accepted on August 12, 1974






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