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J Dent Res 54(1): 25-31, 1975
© 1975 International and American Associations for Dental Research
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Surface-Chemical Studies on Chlorhexidine and Related Compounds: II. Interactions with Monomolecular-Film Systems

RICHARD G. FISHER 1 and RONALD P. QUINTANA 1

1 Surface Chemistry Laboratory, Department of Medicinal Chemistry, College of Pharmacy, University of Tennessee Medical Units, Memphis, Tennessee 38163, USA

Interactions of chlorhexidine and structurally related biguanides with selected monomolecular-film systems (that is, stearic acid, stearyl alcohol, and N-octadecylacetamide) were explored. The data reflected the significance of ionic associations between the compounds and stearic acid films and, in the instance of the biguanide analogs, indicated that the length of the alkyl chain was an important factor in the penetration process.

Submitted on February 8, 1974
Accepted on August 12, 1974






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