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J Dent Res 54(1): 125-130, 1975
© 1975 International and American Associations for Dental Research
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Electron Microscopic Study of the Cytotoxicity of Cadmium and Mercury In Vitro

H. KAWAHARA 1, Y. TAKASHIMA 1, M. NAKAMURA 1, and A. YAMAGAMI 1

1 Tissue Culture Center and Department of Dental Materials, Osaka Dental University, Osaka 540, Japan, and Department of Anatomy, Osaka University Medical School, Osaka 530, Japan

The cells treated with cadmium chloride showed severe changes: ribosomes disappeared, mitochondria showed various degrees of destruction, and the endoplasmic reticulum had a swollen and beadlike appearance. In cells treated with mercuric chloride, ribosomes increased in their density and rosettelike polysomes were predominantly observed. The effects of these two metallic ions were discussed.

Submitted on November 20, 1973
Accepted on August 12, 1974






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