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J Dent Res 53(6): 1387-1391, 1974
© 1974 International and American Associations for Dental Research
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Transport of 14C-Diphenylhydantoin and 14C-Leucine Through Rabbit Crevicular Epithelium

ARNOLD D. STEINBERG 1, HENRY JEFFAY 1, and PAMELA ALLEN 1

1 University of Illinois Medical Center, Chicago, Illinois 60612, USA

Isolated gingival crevices of rabbits were used to quantitate the transport of 14C-diphenylhydantoin and 14C-leucine through noninflamed crevicular epithelium. liC uptake measured in the serum after two-hour application, indicated that both diphenylhydantoin and amino acid were transported and that at the dose levels used, more of the diphenylhydantoin was found in the blood than the amino acid. Very high levels of the drug were found in cerebral cortex while other tissues had much lower levels.

Submitted on September 10, 1973






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