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J Dent Res 53(6): 1323-1329, 1974
© 1974 International and American Associations for Dental Research

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Levels of 5,5-Diphenylhydantoin and Its Major Metabolite in Human Serum, Saliva, and Hyperplastic Gingiva

GORDON J. CONARD 1, HENRY JEFFAY 1, LOUIS BOSHES 1, and ARNOLD D. STEINBERG 1

1 American Dental Association Research Institute, Chicago, Illinois 60611, USA and College of Dentistry, University of Illinois Medical Center, Chicago, Illinois 60612

Levels of 5,5-diphenylhydantoin (DPH) and its para-hydroxy metabolite (HPPH) were measured in serum, saliva, and in segments of hyperplastic gingiva from patients receiving chronic drug therapy. The severity of gingival hyperplasia tends to be associated with higher DPH levels in gingiva and with lower tissue levels of HPPH.

Submitted on November 12, 1973







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