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J Dent Res 53(3): 670-677, 1974
© 1974 International and American Associations for Dental Research
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Prostaglandin-Induced Resorption of the Adult Rat Calvarium

J. MAX GOODSON 1, KENNETH McCLATCHY 1, and CLIFFORD REVELL 1

1 School of Dentistry, University of California, San Francisco, California 94143, USA; University of Michigan Medical Center, Ann Arbor, Michigan 48104, and University of Alberta, Faculty of Dentistry, Edmonton, Alberta, Canada

Prostaglandin E1-containing solutions injected under the skin overlying the calvarium of adult rats produced a visible resorptive lesion within the bone in seven days. The resorptive process was characterized by fibrous replacement of bone matrix and by increased vascularity. Inflammatory cells were not apparent.

Submitted on December 11, 1972




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