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J Dent Res 53(3): 509-515, 1974
© 1974 International and American Associations for Dental Research
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Tissue-Specific Suppression of Differentiation by 5-Bromodeoxyuridine In Vitro

S. A. SCHWARTZ 1 and W. H. KIRSTEN 1

1 Departments of Pathology and Pediatrics, University of Chicago, Chicago, Illinois 60637, USA

Embryonic rat tooth germs were treated with 5-bromodeoxyuridine in vitro. Morphodifferentiation and histodifferentiation were arrested. Epithelial and mesenchymal deoxyribonucleic acid and protein synthesis were unaffected, whereas ribonucleic acid and collagen synthesis were retarded in the mesenchyme only. Inhibition of odontogenesis by this agent appears to be tissue-specific.

Submitted on October 5, 1973






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