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J Dent Res 53(2): 364-368, 1974
© 1974 International and American Associations for Dental Research
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Spiramycin Excretion in Animals: III. A Single Oral Dose in Dogs

S. L. YANKELL 1, F. C. LEUNG 1, J. M. GARDNER 1, and W. S. PAOR 1

1 Biological Sciences Department, Menley & James Laboratories, Philadelphia, Pennsylvania 19101, USA and Smith Kline & French, Ltd., Montreal, Quebec, Canada

Spiramycin concentrations were determined in plasma and parotid and sublingual fluids of unanesthetized dogs 1 to 6 and 24 hours after a single oral dose of the antibiotic. Plasma levels were highest 1 to 4 hours after dosage. Sustained sublingual secretion and peak parotid levels of spiramycin occurred at later collection times.

Submitted on May 29, 1973






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