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J Dent Res 53(2): 352-355, 1974
© 1974 International and American Associations for Dental Research
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Effect of Tetracycline on Norethynodrel-and Mestranol-Induced Dental Caries in Rats

F. T.Y. LIU 1, H. S. LIN 1, and T. H. ALMS 1

1 School of Dentistry, University of Missouri-Kansas City, Missouri 64108, USA

Weanling female rats were given subcutaneous injections of contraceptive steroids (norethynodrel and mestranol), tetracycline supplements in drinking water, or both, for seven weeks. Norethynodrel-mestranol treatment caused a significant increase in dental caries activity; this increase was prevented by intermittent supplements of tetracycline in drinking water.

Submitted on June 28, 1973






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