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J Dent Res 52(6): 1209-1215, 1973
© 1973 International and American Associations for Dental Research
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Phosphoenolpyruvate-Dependent Glucose Transport in Oral Streptococci

CHARLES F. SCHACHTELE 1 and JOHN A. MAYO 1

1 School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA and Department of Biological Sciences, Louisiana State University in New Orleans, New Orleans, Louisiana

Streptococcus mutans, S sanguis, and S salivarius use a phosphoenolpyruvate (PEP)-dependent phosphotransferase system that results in phosphorylation of glucose at carbon 6. This enzyme system is not sensitive to fluoride. Glucose uptake into resting cell suspensions is sensitive to fluoride because of inhibition of intracellular PEP production. The glucose phosphotransferase system is constitutive in oral streptococci.

Submitted on December 26, 1972




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