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J Dent Res 52(5): 1070-1075, 1973
© 1973 International and American Associations for Dental Research
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Preferential Induction of Rough Variants in Streptococcus mutans by Ethidium Bromide

MASAKO HIGUCHI 1, KAEKO ENDO 1, ETSURO HOSHINO 1, and SHIMPEI ARAYA 1

1 Tokoku University, School of Dentistry, Sendai, Japan

Different colonial variants of Streptococcus mutans were studied. Rough variants were induced frequently from an original mucoidtype strain in cultures to which ethidium bromide was added. Rough variants had less insoluble dextranlike polysaccharides than the original mucoid strain. Mitomycin C caused cell lysis in mucoid cells but not in rough cells.

Submitted on September 22, 1972






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