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J Dent Res 52(2): 267-270, 1973
© 1973 International and American Associations for Dental Research
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Distribution and Metabolism of Diphenylhydantoin in Oral and Nonoral Tissues of Ferrets

ARNOLD D. STEINBERG 1, PAMELA M. ALLEN 1, and HENRY JEFFAY 1

1 Department of Periodontics College of Dentistry, and Department of Biological Chemistry College of Medicine, University of Illinois, Chicago, Illinois 60612, USA

Tissue distribution of diphenylhydantoin and metabolites in oral and nonoral tissues of the ferret after administration of single and multiple doses revealed that prolonged administration resulted in high concentrations of unmetabolized DPH in oral mucosa, salivary glands, and gingiva. This suggests a direct role of unmetabolized DPH in the induced gingival hyperplasia.

Submitted on December 8, 1971






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