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J Dent Res 51(6): 1632-1638, 1972
© 1972 International and American Associations for Dental Research
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Embryonic-Fetal Toxicity and Teratogenic Effects of a Group of Methacrylate Esters in Rats

A. R. SINGH 1, W. H. LAWRENCE 1, and J. AUTIAN 1

1 Materials Science Toxicology Laboratories, College of Dentistry and College of Pharmacy, University of Tennessee Medical Units, Memphis, Tennessee 38103, USA

Monomers of five methacrylate esters and acrylic acid were administered at three dose levels to female rats on days 5, 10, and 15 of gestation. The incidences of resorptions, dead fetuses, gross abnormalities, and skeletal malformations are presented for each of these groups. Mean fetal weights also were determined for each group, and those of the monomer-treated groups were significantly smaller (P le 0.01) than those of the untreated controls.

Submitted on September 24, 1971




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