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J Dent Res 51(5): 1421-1425, 1972
© 1972 International and American Associations for Dental Research
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Cholesterol Side-Chain Degradation and Cleft Palate Development in the Rat

J. A. URSICK 1, L. D. ISRAELSEN 1, and D. H. SHAW 1

1 Department of Oral Biology, College of Dentistry, University of Nebraska, Lincoln, Nebraska 68503, USA

The teratogenic action of cholesterol in developing rat fetuses was evaluated by the use of 14C4, 3H-7, and 14C-26 labeled cholesterol. A comparison of radioactivity present in the fetuses indicated that the teratogenic activity of this steroid resides in a metabolize of cholesterol rather than in the intact molecule.

Submitted on July 22, 1971




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