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J Dent Res 51(5): 1388-1393, 1972
© 1972 International and American Associations for Dental Research
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Effects of Local Anesthetics on Epinephrine- and Norepinephrine-Induced Contractions of Rabbit Aortic Strips

M. J. DEASY 1 and V. DI STEFANO 1

1 Eastman Dental Center and Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14620, USA

Rabbit aortic strips were used to investigate and compare the interactions of epinephrine and norepinephrine with cocaine, procaine, and lidocaine. Cocaine potentiated responses to epinephrine and norepinephrine. Responses to epinephrine were antagonized by procaine and lidocaine and responses to norepinephrine were potentiated. Lidocaine possessed some intrinsic activity.

Submitted on June 28, 1971






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