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J Dent Res 51(3): 712-715, 1972
© 1972 International and American Associations for Dental Research
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Spiramycin Excretion in Animals: II. Repeated Oral Doses in Rats

F. C. LEUNG 1, J. M. GARDNER 1, W. S. PAOR 1, and S. L. YANKELL 1

1 Smith Kline & French Ltd., Montreal, Quebec, Canada and Smith Kline & French Laboratories, Philadelphia, Pennsylvania, USA

After 7 to 14 spiramycin doses, plasma and selected tissues were assayed for residual antibiotic. Plasma contained detectable spiramycin only in samples taken 24 hours after the last 400 mg/kg dose. After 100 to 400 mg/kg levels, spiramycin remained in mandibular gingiva and bone at least seven days. Parotid and submaxillary glands contained antibiotic 24 hours after 25 to 400 mg/kg doses and 14 to 21 days after 400 mg/kg doses.

Submitted on February 25, 1971






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