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J Dent Res 51(2): 657-662, 1972
© 1972 International and American Associations for Dental Research
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Lack of Relationship Between the Degree of Induced Gingival Hyperplasia and the Concentration of Diphenylhydantoin in Various Tissues of Ferrets

ARNOLD D. STEINBERG 1, JULIAN ALVAREZ 1, and HENRY JEFFAY 1

1 Department of Periodontics, College of Dentistry, and Department of Biological Chemistry, College of Medicine, University of Illinois Medical Center, Chicago, Illinois 60612, USA

Ferrets that were given 5-5 diphenylhydantoin developed various degrees of gingival hyperplasia. Analysis for 5-5 diphenylhydantoin did not show a correlation between the degree of hyperplasia, concentrations of the drug in the various tissues, or turnover of protein-3H proline. Highest concentratrations of the drug were found in oral mucosa, salivary glands, and adrenal glands, and gingiva concentrations were low.

Submitted on April 30, 1971




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