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J Dent Res 51(1): 131-143, 1972
© 1972 International and American Associations for Dental Research
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Effect of a Dorsal Dermal Surgical Wound on the Chemical Response of Rat Abdominal Skin to Chronic Administration of Sodium Diphenylhydantoin

PENG-TUNG HSU CHENG 1 and P. H. STAPLE 1

1 Department of Oral Biology, School of Dentistry, State University of New York at Buffalo, Buffalo, New York 14226, USA

A dorsal dermal surgical wound inflicted five days before excision of abdominal skin from young rats that were under treatment with daily injections of sodium diphenylhydantoin (100 or 50 mg/kg) greatly modified the dermal chemical response to this drug that was observed in unwounded animals. Sodium diphenylhydantoin failed to increase wound rupture strength.

Submitted on December 24, 1970






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