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J Dent Res 50(4): 888-891, 1971
© 1971 International and American Associations for Dental Research
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Effect of Insulin on Caries Activity in the Rat

RICARDO F. BORGHELLI 1, FRANCISCO C. H. DEVOTO 1, ROSA N. LAZZARI 1, JORGE ERAUSQUIN 1, and VIRGILIO G. FOGLIA 1

1 Institute of Physiology, School of Medicine and Department of Embryology and Histology, School of Dentistry, University of Buenos Aires, Argentina

The effect of insulin on dental caries in pancreatectomized and nonpancreatectomized white rats was studied. The experimental rats were pancreatectomized to 95%. All rats were killed 30 days after the operation and autopsies were performed on both experimental and control rats. The results showed a significant decrease of caries activity in nonpancreatectomized rats injected with insulin, as compared with the activity in normal controls; increased caries activity in pancreatectomized rats; and suppression of the cariogenic effect of pancreatectomy by insulin that was in direct relation to the dose of insulin.

Submitted on April 13, 1970






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